Translational Methods
Past Awards
The CCTSI is pleased to announce the Translational Methods Program awardees. These positions are funded by the NIH/NCRR grant to the CCTSI.
2023 Translational Methods Program Awards
| Investigators | Affiliation | Project Title |
| Brad Nelson, DVM, PhD Katie Sikes, PhD | Colorado State University C. Wayne McIlwraith Translational Medical Institute | An Improved Translational Model of Ovine Post-Traumatic Osteoarthritis |
| Alex Barker, PhD Lorna Browne, MD | CU Anschutz Medical Campus CU School of Medicine CU Anschutz Medical Campus Children's Hospital Colorado | Development of motion robust ultrasound gating to enable fetal cardiovascular MRI of congenita heart disease |
2022 Translational Methods Program Awards
| Investigators | Affiliation | Project Title |
| Jessica Metcalf, PhD Susan Lana, PhD | Colorado State University College of Agriculture Colorado State University Flint Animal Cancer Center | Evaluating low-biomass microbial communities associated with spontaneous canine tumors as a translational model for human disease |
| Julie Moreno, PhD Karyn Hamilton, PhD | Colorado State University Center for Healthy Aging Colorado State University Center for Healthy Aging | Hartley guinea pigs: A translational model of spontaneous and progressive neurodegeneration |
| Elizabeth Juarez-Colunga, PhD | CU Anschutz Medical Campus CU School of Public Health | Developing novel methods for dynamic prediction of highly variable outcomes in adult epilepsy patients |
| Cynthia Armstrong, PT, DPT, CHT, CLT Christodoulos Kaoutzanis, MD | CU Anschutz Medical Campus CU School of Medicine CU Anschutz Medical Campus CU School of Medicine | Establishing guidelines for optimal manual lymphatic drainage (MLD) |
| Martin Breuss, PhD | CU Anschutz Medical Campus CU School of Medicine | Targeted long-read sequencing for parental haplotype determination of diagnostic variants |
| Manisha Patel, PhD | CU Anschutz Medical Campus CU School of Pharmacy | Validating larval zebrafish brain activity using a novel non-invasive multielectrode array system |
| Jenny Zablah, MD Debanjan Mukherjee, PhD | CU Anschutz Medical Campus Children’s Hospital Colorado CU Boulder College of Engineering and Applied Science | Computational fluid dynamic assessment of patients with congenital heart disease from 3D rotational angiography obtained in the catheterization laboratory |
2021 Translational Methods Program Awards
| Investigators | Affiliation | Project Title |
| David Prawel, PhD Bernard Seguin, VMD | Colorado State University Walter Scott, Jr. College of Engineering College of Veterinary Medicine and Biomedical Sciences | Testing A Novel Approach to Healing Critical Bone Defects |
| Brian Scansen, DVM, MS | Colorado State University College of Veterinary Medicine and Biomedical Sciences | A novel cardiac CT based technique to assess primary mitral regurgitation in a naturally occurring large animal model |
| John Rice, PhD | CU Anschutz Medical Campus CU School of Public Health | Innovations in the design and analysis of studies to improve childhood vaccination rates |
| Ryan Peterson, PhD Carsten Goerg, PhD | CU Anschutz Medical Campus CU School of Public Health | Visual Interactive Model Selection for Determining Predictors of Lung Function |
| Virginia Ferguson, PhD | CU Boulder College of Engineering & Applied Science | Development of a novel animal model for osteochondritis dissecans |
| Jeffrey Kieft, PhD | CU Anschutz Medical Campus CU School of Medicine | Controlling the transcriptome with engineered and customized non-coding RNAs |
| Mark Borden, PhD David Thomas, PhD | CU Boulder CU Anschutz Medical Campus | Endoskeletal nanodrops for x-ray photoacoustic dosimetry |
2020 Translational Methods Program Awards
| Primary Investigator | Co-Investigators | Project Title |
Frank Dinenno, PhD | Colorado State University College of Health and Human Sciences Department of Health and Exercise Science | A novel approach to real-time monitoring of erythrocyte ATP release as a function of hypoxia |
| Katerina Kechris, PhD | CU Anschutz Medical Campus Colorado School of Public Health Department of Biostatistics and Bioinformatics | SiNorm: a novel statistical methodology for normalizing signal intensities in preclinical MRI |
| Julia Wrobel, PhD | CU Anschutz Medical Campus CU School of Public Health Department of Biostatistics and Bioinformatics | Network Analysis of the Ovarian Tumor Microenvironment |
| Eva Grayck, MD | CU Anschutz Medical Campus CU School of Medicine Department of Pediatrics Division of Pediatric Critical Care | Development of Novel Electron Paramagnetic Resonance Tools Necessary for In Vivo Assessment of Free Radical Production in Heart Failure |
| Keith Koch, PhD | CU Anschutz Medical Campus CU School of Medicine Department of Medicine Division of Cardiology | A soft-to-stiff, phototunable hydrogel, 96-well high-content screening platform for the study of fibrosis mechanoregulation and the identification of novel antifibrotic compounds |
| Mia Smith, DVM, PhD | CU Anschutz Medical Campus Barbara Davis Center for Diabetes Department of Pediatrics Division of Basic Research | Simultaneous detection of antigen specificity, V(D)J repertoire, and gene expression in single B cells |
| Michael V. Zaretsky, MD | Children’s Hospital Colorado Colorado Fetal Care Center, Medical Director CU Anschutz Medical Campus CU School of Medicine Department of Obstetrics and Gynecology Division of Maternal Fetal Medicine | In utero targeting of the CFTR gene using CRISPR/Cas9 |
2018 - 2019 Translational Methods Program Awards
| Primary Investigator | Co-Investigators | Project Title |
| Kristina Legget, PhD | Korey Wylie, PhD | Development of a novel method for whole-brain multivariate connectivity analysis to assess relationships between clinical symptoms and brain connectivity in psychiatric disorders |
| Rebekah Kading, PhD | CD Snow, PhD | Edible, Biodegradable, Barcode Crystals for Arthropod Surveillance |
| Mark Stenglein, PhD | Unraveling rotavirus reassortment: A novel amplicon-NGS method for genotyping Rotavirus A strains from clinical samples | |
| David Westerly, PhD | Development of a nanosecond class pulsed x-ray source for translational research applications | |
| Thomas Jansson, MD | Steven Abman, MD | Development of a guinea pig NICU for transformative studies of prematurity |
| Min Choi, PhD | Ann Halbower, MD | Non-Contact Remote Breathing Analysis through Visualization of Thermal and CO2 Flow (VTCF) |
| Ryan Lanning, MD, PhD | Traci Lyons, PhD | Optical Lymphangiography of Murine Mammary Tissue during Involution and in Postpartum Breast Cancer |
| Petter Bjornstad, MD | Phase Contrast MRI to Calculate Glomerular Filtration Rate Study |
2017 Translational Methods Program Awards
| Primary Investigator | Co-Investigators | Award Phase | Project Title |
| Debnath Chatterjee | Phase I | Novel Technology for Continuous Quantitative Monitoring of Uterine Tone | |
| James Carollo | Willy Boucharel, Richard Pimentael, David Polaner | Phase II | Multichannel Intraoperative EMG Recording of Myometrium for Continuous Monitoring of Uterine Tone |
| Achim Klug | Phase I | Measuring extracellular calcium concentration in the brain in-vivo | |
| Charles Henry | Phase II | Novel electrochemical sensors extracellular calcium measurements | |
| Leah Villegas | Phase I | Pharmacokinetic and pharmacodynamic evaluation of targeted therapies in the pulmonary circulation | |
| MyPhuong Le | Phase II | Dosing, sampling and analysis of the pulmonary circulation for PK/PD studies of pulmonary therapies | |
| David Beckham | Phase I | Development of RNA flow cytometry analysis for genomic Zika virus RNA detection | |
| Eric Clambey | Phase II | Identification and purification of virally-infected cells based on RNA expression |
2016 Translational Methods Program Awards
| Primary Investigator | Co-Investigators | Award Phase | Project Title |
| Kurt Stenmark | Phase I | Novel Durg Screening Method for Pulmonary Hypertension | |
| Daniel LaBarbera | Linfeng Li | Phase II | 3D culture models for high throughput drug discovery targeting pulmonary hypertension |
| Traci Lyons | Phase I | Imaging Technique to Correlate Inflamed Breast Cancer and Lymph Node Metastasis | |
| Natalie Serkova | Phase II | Non-Invasive Muli-Parametric MRI on Lymph Node Involvement and Inflammation Status in Breast Cancer | |
| Nicholas Walter | Phase I | Pathogen-Targeted Transcriptional Profiling in Human Samples: A Tool for Monitoring Treatment Responses in Tuberculosis | |
| Carol Wilusz | Joe Russo | Phase II | Novel method for selecting M.abscessus RNAs from infected human tissue samples |
2015 Translational Methods Program Awards
| Primary Investigator | Co-Investigators | Award Phase | Project Title |
| Ken Maclean | Phase I | Enhanced bio delivery of cystathionine as a treatment for acute liver disease failure, nephrotoxicity and vascular calcification | |
| Tom Anchorduquoy | Phase II | Improving cystathionine in a manner which allows increased solubility and gradual release in vivo | |
| Aviva Abosch | Phase I | Sensory Gating with a Microelectrode during deep brain stimulation surgery | |
| Keeran Maharajh | Phase II | Developing a method to measure auditory agting during deep brain stimulation surgery | |
| Dwight Klemm | Kathleen Gavin, Wendy Khort | Phase I | Development of a method to distinguish human adipocytes arising from distinct progenitor cells |
| Rick Reisdorph | Nichole Reisdorph | Phase II | Development of proteomics and metabolomics methods to distinguish between human adipocytes arising from distinct progenitor cells |
| Catherine Lozupone | Phase I | Targeted metabolomics of producs of bacterial ploycyclic aromatic hydrocarbon degradation in the nasal cavity | |
| Michael Wempe | Phase II | Optimization and Validation of Mass Spectrometry-based Assays for the Measurement of Polycyclic Aromatic Hydrocarbons (PAHs) and their metabolites |
2014 Translational Methods Program Awards
| Primary Investigator | Co-Investigators | Award Phase | Project Title |
| Nguyen Vu | Phase I | Flow Cytrometric Analysis to Define Gut Microbiota | |
| Xiaoli Yu | Phase II | Development of high affinity phage peptide probes for rapid identification and characterization of the microbiota subsets that contribute to graft-versus-host disease (GVHD) pathogenesis | |
| Joseph Hurt | Kathleen Connell | Phase I | Novel biomechanical measurements of the uterine cervix at parturition |
| Virginia Ferguson | Mark Rentschler | Phase II | Novel biomechanical measurements of the uterine cervix at parturition |
| Eoin McNamee | Phase I | Mouse colonography for non-invasive assessment of intestinal architecture during colitis and colitis associated colon cancer | |
| Natalie Serkova | Phase II | Small Animal microCT Colongraphy and FDG-PET for Non-Invasive Imaginf of Colitis and Colitis Inflammation | |
| Jane Reusch | Judy Regensteiner | Phase I | Development of non-invasive systemic vascular characterization for diagnosis and prognosis of systemic vascular disease |
| Kendall Hunter | Phase II | Echo- and MR-based quantitative assessment of the systemic vasculature |
2012 Translational Methods Program Awards
| Primary Investigator | Co-Investigators | Award Phase | Project Title |
| Pepper Schedin | Phase I | Non-Invasive Macrophage Imaging in Breast Cancer Models | |
| Natalie Serkova | Phase II | Iron Oxide Based T2-MRI for Imaging Macrophage Recruitment into Breast Cancer | |
| Kristen Uhler | Phase I | Audiologist needs novel method for advanced analysis techniques of auditory evoked potentials and computer programming to develop sound stimuli | |
| Daniel Tollin | Nathaniel Greene | Phase II | Data acquisition and analysis software for measurements of mismatch negativity and acoustic change complex |
| Eric Clambey | Phase I | The development of histology-based flow cytometry for multi-parameter, quantitative analysis of cell pupulations in situ | |
| Richard Benninger | Phase II | Multi-parameter quantatative analysis of cellular populations in-situ |
2011 Translational Methods Program Awards
| Primary Investigator | Co-Investigators | Award Phase | Project Title |
| Anna Ivanschenko | Gordon Lindberg | Phase I | Multiplex Point-of-Care Diagnostic Anemia Testing in Critically Ill Burn Patients |
| Mark Duncan | Phase II | Multiplex Point-of-Care Diagnostic Anemia Testing in Critically Ill Burn Patients |
2010 Translational Methods Program Awards
| Primary Investigator | Co-Investigators | Award Phase | Project Title |
| Dennis Voelker, PhD | Bob Murphy, PhD, School of Medicine, Pharmacology | Phase II | A highly sensitive method for rapid and large-scale quantification of phosphatidylglycerol and phosphatidylinositiol in pulmonary surfactant from patients with acute and chronic lung diseases. |
| Daniel Tollin, PhD | Kanthaiah Koka, PhD, School of Medicine, Physiology and Biophysics | Phase II | Data acquisition and analysis software for smooth pursuit eye movement measurements in infants |
| Wenbo Zhou, PhD | Phase II | Development of novel method to generate sensory neuron from human induced pluripotent stem (iPS) cells for varicella zoster virus infection and latency study | |
| Mark Laudenslager, PhD | Phase II | Salivary alpha amylase as a biomarker of acute stress reactivity |
2009 Translational Methods Program Awards
| Primary Investigator | Co-Investigators | Award Phase | Project Title |
| Lori A. Walker, PhD | John S. Walker, PhD | Phase II | New Methods for Assessing Human Blood Vessel Mechanical Function |
| Mark S. Brown, PhD | Phase II | Development of a Magnetic Resonance Spectroscopy-Based Measure of GABA Concentrations for Studies of Neurodevelopment Disorders | |
| Kai R. Larsen, PhD | Jintae Lee, PhD and Zoya Voronovich, University of Colorado Boulder | Phase II | The Inter-Nomological Network for Behavioral Health |
| Lynne Bemis, PhD | Won Park, PhD, University of Colorado Boulder, Engineering | Phase II | Gold Nanoparticle Assay for the Detection of Multiple MicroRNAs in Patient Samples |