Child and Maternal Health Pilot Program (CMH-Pilot)

Past Awards

The Colorado Clinical and Translational Sciences Institute (CCTSI) is pleased to announce the CCTSI Pilot Grant Awardees for the Child and Maternal Health Pilot (CMH-Pilot) program. Congratulations to the awardees of the grants in these programs.

2020 Child and Maternal Health Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Katja Gist, DOChildren’s Hospital Colorado
CU School of Medicine
Department of Pediatrics
Division of Cardiology
Evaluation of microRNA's and metabolome in acute kidney injury after congenital heart surgery
Anastacia Garcia, PhDChildren’s Hospital Colorado
CU School of Medicine
Department of Pediatrics
Section of Cardiology
Peripheral Mononuclear Cells as Biomarkers for Myocardial Mitochondrial Function in Single Ventricle Congenital Heart Disease Patients
Maya Haasz, MDChildren’s Hospital Colorado
CU School of Medicine
Department of Pediatrics
Section of Pediatric of Emergency Medicine
Safe storage of firearms: what do parents know?
Amy C. Kelly, PhDCU Anschutz Medical Campus
CU School of Medicine
Department of Obstetrics and Gynecology
Division of Reproductive Sciences
Regulation of O-GlcNAc transferase and serotonin release in the human placenta by mTOR signaling
Julie Pires da Silva, PhDCU Anschutz Medical Campus
CU School of Medicine
Department of Medicine
Division of Cardiology
Branched Chain Amino Acids in Pediatric Dilated Cardiomyopathy

2018 Child and Maternal Health Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Anastacia Garcia, PhDDivision of Cardiology
Department of Pediatrics
School of Medicine
CU Denver - Anschutz Medical Campus
Myocardial Effects of Phosphodiesterase-5 in Single Ventricle Congenital Heart Disease
Laurie Sherlock, MDDivision of Neonatology
Department of Pediatrics
School of Medicine
CU Denver - Anschutz Medical Campus
The impact of SOD3 distribution on alveolar and pulmonary vascular development
Claire Stokes, MD, MPHDivision of Hematology-Oncology
Department of Pediatrics
School of Medicine
CU Denver - Anschutz Medical Campus
Utilizing Urinary Biomarkers of Kidney Injury to Predict Acute Kidney Injury and Delayed Clearance of High Dose Methotrexate in Children with Leukemia
Owen Vaughan, PhDDivision of Reproductive Sciences
Department of Obstetrics and Gynecology
School of Medicine
CU Denver - Anschutz Medical Campus
The role of myocardial lipid metabolism in developmental programming of cardiac hypertrophy by maternal obesity
Gretchen Domek, MD, MPhilDivision of General Academic Pediatrics
Department of Pediatrics
School of Medicine
CU Denver - Anschutz Medical Campus
Promoting language development through a primary care-based intervention in infancy

2017 Child and Maternal Health Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Stephanie Chassen, MDDivision of Neonatology
Department of Pediatrics
School of Medicine
CU Denver - Anschutz Medical Campus
Placental Transport of Fatty Acids in Intrauterine Growth Restriction
Andra Dingman, MDDivision of Child Neurology
Department of Pediatrics
Children’s Hospital Colorado
Advanced Imaging of Brain White Matter After Perinatal Hypoxic Ischemic Encephalopathy
Rachel Rodel, MDDivision of Maternal Fetal Medicine
Department of Obstetrics and Gynecology
School of Medicine
CU Denver - Anschutz Medical Campus
Fasting and Postprandial Breast Milk Composition in Mothers with Type 2 Diabetes as a Function of Glycemic Control and the Effect on the Infant Microbiome
Sara Saporta-Keating, MDDivision of Pediatric Infectious Diseases
Department of Pediatrics
School of Medicine
CU Denver - Anschutz Medical Campus
Humoral immune development in the first year of life: Paradigms to enhance early vaccine-induced protection against infection
Michael Swanson, PhDDivision of Genetics
Department of Pediatrics
School of Medicine
CU Denver - Anschutz Medical Campus
Development of Effective Treatments for NKH Based on the Stabilization of the Glycine Cleavage Enzyme System P-Protein

2016 Child and Maternal Health Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Sarah Borengasser, PhDSection of Nutrition
Department of Pediatrics
School of Medicine
CU Denver - Anschutz Medical Campus
Role of maternal obesity and preconception micronutrient supplementation on DNA methylation in umbilical cord blood and infant outcomes
Shanlee Davis, MDDivision of Endocrinology
Department of Pediatrics
School of Medicine
CU Denver - Anschutz Medical Campus
Cardiometabolic profiles of pubertal boys with Klinefelter syndrome with or without one year of exogenous testosterone treatment
Vanessa Sherk, PhDDivision of Endocrinology, Metabolism & Diabetes
Department of Medicine
School of Medicine
CU Denver - Anschutz Medical Campus
Metabolic phenotype, insulin signaling and lipotoxicity in osteoblasts from lean and overweight adolescent girls
Curtis Coughlin III, MS, MBeSection of Clinical Genetics and Metabolism Department of Pediatrics
School of Medicine
CU Denver - Anschutz Medical Campus
Dried Blood Spot Screening For Pyridoxine Dependent Epilepsy
Torri Metz, MD, MSDivision of Maternal-Fetal Medicine
Department of Obstetrics and Gynecology
University of Colorado School of Medicine
Denver Health and Hospital Authority
Detection of Prenatal Marijuana Use in a Legalized Environment: Comparison of Self-Report and Umbilical Cord
Homogenate Sampling
Amanda N’zi, PhDDepartment of Pediatrics
Kempe Center
CU Denver - Anschutz Medical Campus
An innovative approach to enhancing positive parenting practices in caregivers of young children at-risk for the negative impact of toxic stress on health outcomes using mobile application technology: An end-user study design

2015 Child and Maternal Health Pilot Program Awards

Principal InvestigatorAffiliationProject Title
James Feinstein, MD, MPHSchool of Medicine, Department of Pediatrics, General Pediatrics, University of Colorado Denver | Anschutz Medical CampusThe Degree and Duration of Outpatient Pediatric Polypharmacy
Marisa Friederich, PhDSchool of Medicine, Department of Pediatrics, Genetics and Metabolism, University of Colorado Denver | Anschutz Medical CampusCellular transdifferentiation of fibroblasts for functional analysis of newly identified genetic causes in mitochondrial diseases
Silvia Giugliano, MSc, PhDSchool of Medicine, Department of Pediatrics, Gastroenterology, Hepatology and Nutrition, University of Colorado Denver | Anschutz Medical CampusHuman Trophoblasts: Active Immunological Barrier that Prevents Transmission of Hepatitis C virus at the Maternal-Fetal interface
Peter Russell, MDSchool of Medicine, Department of Pediatrics, Clinical Genetics and Metabolism, University of Colorado Denver | Anschutz Medical CampusMechanisms of Developmental Programming in Stem Cells from Offspring of Obese Mothers
Clyde Wright, MDSchool of Medicine, Department of Pediatrics, Neonatology, University of Colorado Denver | Anschutz Medical CampusThe implication of attenuated systemic inflammatory stress-induced ET1 expression in pathogenesis of persistent pulmonary hypertension of the newborn

2014 Child and Maternal Health Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Colleen G. Julian, PhDSchool of Medicine, Department of Medicine, Division of Biomedical Informatics and Personalized Medicine, University of Colorado Denver | Anschutz Medical CampusHypoxia-associated impairment of fetal growth: epigenomic perspectives
Austin Larson, MDSchool of Medicine, Department of Pediatrics, Division of Genetics and Metabolism, University of Colorado Denver | Anschutz Medical CampusUse of whole exome sequencing of parent-child trios to detect novel mutations in patients with septo-optic dysplasia
Minghua Tang, PhDSchool of Medicine, Department of Pediatrics, Division of Nutrition, University of Colorado Denver | Anschutz Medical CampusHigh protein consumption from meat vs. dairy as complementary foods on infant growth, body composition and gut microbiome: a controlled feeding study
Douglas J. Kominsky, PhDSchool of Medicine, Department of Anesthesiology, University of Colorado Denver | Anschutz Medical CampusEpithelial IL-10 signaling in mucosal homeostasis and inflammation resolution
Tamara Terzian, PhDSchool of Medicine, Department of Dermatology, University of Colorado Denver | Anschutz Medical CampusIdentifying the genetic determinants of Giant Congenital Nevi

2013 Child and Maternal Health Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Michelle Brock, MDFellow, Pediatrics/Pulmonary, University of Colorado Denver | Anschutz Medical CampusRisk Reduction for Sudden Unexpected Infant Death in Children of Teenage Parents
James Gaensbauer, MDFellow, Pediatrics/ Infectious Disease, University of Colorado Denver | Anschutz Medical CampusThe impact of parasitic infection in infancy on Haemophilus influezae type b vaccine response
Kevin Messacar, MDFellow, Pediatrics/Infectious Disease, University of Colorado Denver | Anschutz Medical CampusClinical Characteristics, Etiology, Epidemiology, and Outcomes of Pediatric Patients with Aseptic Meningitis and Encephalitis
Stephanie Nakano, MDFellow, Pediatrics/ Cardiology, University of Colorado Denver | Anschutz Medical CampusChronic Phosphodiesterase 3 Inhibitor Treatment in Pediatric Heart Failure
Uyen Truong, MDAssistant Professor, Pediatrics/ Cardiology, University of Colorado Denver | Anschutz Medical CampusWall shear stress measured by MRI determines outcomes in children and adolescents with pulmonary arterial hypertension
Bridgett Young, PhDFellow, Pediatrics/ Nutrition, University of Colorado Denver | Anschutz Medical CampusImpact of Maternal Obesity and Diabetes on Breast Milk Composition and Infant Adiposity
Scott Auerbach, MDAssistant Professor, Pediatrics/ Cardiology, Children's Hospital ColoradoGenetics Modifiers of Disease in Duchenne’s Muscular Dystrophy: Association of Renin-Angiotensin-Aldosterone-System (RAAS) and Innate Immune System Polymorphisms with Inflammatory Cytokine Levels
Xueni Chen, MDInstructor, Allergy & Clinical Immunology, University of Colorado Denver | Anschutz Medical CampusElucidation of Conformational epitopes of peanut allergens essential for allergic reactions
Lisa Meltzer, PhDAssistant Professor, Pediatrics, National Jewish Health; Assistant Professor of Family Medicine, Pediatrics/ Behavioral Health, University of Colorado Denver | Anschutz Medical CampusSleep, Lung Function, and Markers of Inflammation in Adolescents with Asthma

2012 Child and Maternal Health Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Peter Baker, MDFellow, Pediatrics, Clinical Genetics & Metabolism, University of Colorado Denver | Anschutz Medical CampusAtypical non-ketotic hyperglycinemia: a heterogeneous condition caused by disorders of iron-sulfur cluster biogenesis
Edward GarridoSenior Instructor, Pediatrics/Kempe Center, University of Colorado Denver | Anschutz Medical CampusViolence Exposure and its Impact on Executive Functions and Violence Perpetration
Patricia Huguelet, MDAssistant Professor, Obstetrics & Gynecology, University of Colorado Denver | Anschutz Medical CampusValidation of the “My Mood” (M3) Mental Screen Among Perinatal Adolescents
Taizo Nakano, MDFellow, Pediatric Hematology/ Oncology, University of Colorado Denver | Anschutz Medical CampusThe development of patient specific mimotope vaccines to enhance the endogenous T-cell response against Neuroblastoma
Shelley Miyamoto, MDAssistant Professor, Pediatrics/ Cardiology, University of Colorado Denver | Anschutz Medical CampusImpact of Phosphodiesterase inhibition on cAMP Expression in Hypoplastic Left Heart Syndrome
Kenneth Hurt, MD, PhDObstetrics & Gynecology/Basic Reproductive Sciences, University of Colorado Denver | Anschutz Medical CampusA novel signaling pathway in preterm labor: uterine tocolysis and transplacental fetal
David Brumbaugh, MDPediatrics/Gastroenterology, Hematology, and Nutrition, University of Colorado Denver | Anschutz Medical CampusIdentification of a clinically useful measure of nutritional status in children with SMA
Angela Czaja, MD, MScAssistant Professor, Pediatrics/Critical Care, University of Colorado Denver | Anschutz Medical CampusPhysician Decision Making in Medication Prescribing
Meghan Donnelly, MDFellow, Obstetrics & Gynecology/Maternal Fetal Medicine, University of Colorado Denver | Anschutz Medical CampusCervical Ultrasound Elastography for the Prediction of Preterm Birth

2011 Child and Maternal Health Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Colm Collins, PhDPediatrics Department, School of Medicine, University of Colorado Denver | Anschutz Medical CampusHSP 90 in Inflammatory Bowel Disease: Role of Pathogenesis and Therapeutic Target
Kimberly D'Anna, PhDPsychiatry Department, School of Medicine, University of Colorado Denver | Anschutz Medical CampusMaternal Hair Cortisol and Fetal Adrenal as Markers of Perinatal Stress Leading to Adverse Perinatal Outcomes
Thomas Flass, MD MSPediatrics Department, School of Medicine, University of Colorado Denver | Anschutz Medical CampusCirrhosis in Children with Cystic Fibrosis: Possible Links with Intestinal Inflammation, Permeability, and Alterations in the Intestinal Microbiome
Cameron Gunville, DOPediatrics Department, School of Medicine, University of Colorado Denver | Anschutz Medical CampusVitamin D Levels in Preterm Infants with Viral Lower Respiratory Tract Infection
Jillian Sullivan, MDPediatrics Department, School of Medicine, University of Colorado Denver | Anschutz Medical CampusThe Effect of an Oral Fructose Challenge in Children with Non-Alcoholic Fatty Liver Disease
Caroline Kulesza, PhDMicrobiology Department, School of Medicine, University of Colorado Denver | Anschutz Medical CampusDevelopment of a Novel HCMV Vaccine Strategy
Catherine Lozupone, PhD The Effects of Diet Alteration Strategies on the Gut Microbiota of Children with Autism
Regina M. Reynolds, MDPediatrics Department, School of Medicine, University of Colorado Denver | Anschutz Medical CampusCorrelation of Body Composition with Nutrient Intake as a Means to Determine Optimal Growth Rates in Extremely Low Birth Weight Infants
Michael E. Yaeger, PhDPediatrics Department, School of Medicine, University of Colorado Denver | Anschutz Medical CampusRole of Fibrocytes and Myeloid Derived Suppressor Cells in Persistent Inflammation Associated with Pediatric Pulmonary Hypertension

2010 Child and Maternal Health Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Jennifer Armstrong-Wells, MDUniversity of Colorado Denver | Anschutz Medical Campus/Children's Hospital ColoradoInflammation as a Risk Factor for Symptomatic Perinatal Stroke & Brain Ingury
David Brumbaugh, MDDivision of Pediatric Gastroenterology, Hepatology & Nutrition, Children's Hospital Colorado/University of Colorado Denver | Anschutz Medical Campus PediatricsMagnetic Resonance Imaging for Quantitation of Depot-Specific Adiposity and Liver Fat in Infancy
Joanne Masterson, PhDPediatric Gastroenterology, Hepatology & Nutrition, School of Medicine, Children's Hospital ColoradoEosinophils Role in Tissue Remodeling with Pediatric Inflammatory Bowel Diseases
Samuel Dominguez, MD, PhDSection of Infection Disease, Pediatrics, Children's Hospital ColoradoClinical Epidemiological, and Inflammatory Response Studies of Pediatric Patients with Novel Swine-Origin Influenza A (H1N1) Infection
Nancy Donelan-McCall, PhDPrevention Research Center for Family and Child Health, Pediatrics, University of Colorado Denver | Anschutz Medical CampusTranslating the DANCE (Dyadic Assessment of Naturalistic Caregiver-Child Interaction and Environment) to Clinical Practice for the Promotion of Competent Parenting
Carmen Sucharov, PhDCardiology Division, Department of MedicineB-Adrenergic Receptor Regulation in Pediatric Heart Failure
Joanne Valvano, PhDUniversity of Colorado Denver | Anschutz Medical CampusManual Task Analysis Discerns Limitations in Motor Control in Children with Down Syndrome
Virginia Winn, MD, PhDOB/GYN, School of Medicine, University of Colorado Denver | Anschutz Medical CampusPregnancy-Associated Plasma Protein 2 (PAPP-A2), A Potential Biomarker for Preeclampsia

2009 Child and Maternal Health Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Neil Box, PhDSchool of Medicine, DermatologyGene and environmental influences on melanoma risk phenotypes in Colorado Children
Karim El Kasmi, MD, PhDSchool of Medicine, Pediatrics, Pediatric Gastroenterology, Hepatology and NutritionRole of innate immunity in the pathogenesis of parenteral nutrition associated liver injury in infants
Cindy Freehauf, RN, MS, CGCSchool of Medicine, PediatricsThe Oxidative stress and inflammation makers in homocysteimia due to cystathionine beta-synthase deficiency: investigation of their presence and contribution to the natural history of the disease across the life span of affected individuals and the impact of taurine on these markers
Karen Jonscher, PhD; Virginia Ferguson PhDSchool of Medicine, Anesthesiology; College of Engineering, Mechanical EngineeringCorrelating Biomechanical and Biochemical Mechanisms to Predict Preterm Premature Rupture of Membranes (PPROM) in Pregnancy
Jenn Leiferman, PhDSchool of Public Health, Epidemiology DepartmentThe effect of an antenatal physical activity pilot intervention on maternal stress, biomarkers, and preterm delivery
Ellyn Matthews, PhD; Madalynn Neu, PhD, RNCollege of Nursing, NursingCaregiver-Child Sleep Patterns and Distress During Maintenance Therapy for Acute Lymphocytic Leukemia
Yogendra Raol, PhDSchool of Medicine, PediatricsPotassium channel opener for the prevention of seizures and neuronal injury following neonatal hypoxia-ischemia
Nancy West, PhDSchool of Public Health, EpidemiologyThe Environmental Factors in Early Life, DNA Methylation, and Fetal Origins of Diseases Across the Lifespan
Samantha Woodruff, MDChildren's Hospital Colorado, Pediatric GastroenterologyMechanisms of Esophageal Fibrosis