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Pragmatic research spans a wide variety of research activities, and research can be more or less pragmatic in different ways. Pragmatic research:
Use the tabs below to learn more about resources, education and consult requests available to CCTSI investigators to support pragmatic research.
We partner with ACCORDS Education and the Pragmatic Research and Trials Core for pragmatic research consultations.
The Colorado Pragmatic Research in Health Conference (COPRH Con) is a national conference hosted by The Adult and Child Center for Outcomes Research and Delivery Science (ACCORDS) and co-sponsored by the CCTSI with the purpose of training and engaging researchers in methods and applications that support research for having a real world impact. COPRH Con is ideal for clinical and translational researchers, including statisticians, dissemination and implementation scientists, health services and public health researchers, program evaluators. Junior faculty with career development awards, fellows, and anyone wanting to learn and apply new methods directly from world-renowned experts are encouraged to attend.
Pragmatic Research in Health (pragmaticresearch.org) brings together established and emerging pragmatic methods, measures, and models, many of which come from the blossoming field of dissemination and implementation (D&I) science. These methods help to ensure that pragmatic research is not seen as messy or poorly done research, but rather as both relevant and rigorous.
This guide may be used as a comprehensive, stage-by-stage guide to planning and conducting pragmatic research, or may also be navigated by jumping directly to topics of interest. Each section includes extra resources such as videos, publications and links to key resources – expand the right-hand sidebars in each section to access these items.
Pragmatic research consultations are available for all CCTSI members through the ACCORDS Pragmatic Research and Trials Core . These free consultations can provide advice on pragmatic study design, mentorship, resource navigation and collaboration.
To request a consultation, please complete the ACCORDS Consultation Request, and select "Pragmatic Research and Trials Core."
Request a Free Consultation
The goal of the CCTSI’s Pragmatic Electronic Health Record (EHR)-Embedded Trials (PEET) program is to establish infrastructure and procedures to facilitate pragmatic trials through EHR integration. PEET addresses clinical and translational science challenges by reducing the burden on participants, clinicians, and researchers in research approval and conduct. This is achieved through partnerships with health system and university research regulatory, informatics, and data science units. Community engagement in designing and implementing patient-centered materials and protocols aims to build trust and increase trial participation. Scientific advisory on pragmatic trial design, dissemination and implementation science, and community engagement enhances research rigor. PEET supports multiple EHR integration features, including streamlined resources for decentralized clinical trials (e.g., e-consent, portal-based patient recruitment), cohort identification, randomization, intervention delivery, trial accrual monitoring, and data collection and analysis.
To develop and refine processes for local approval and conduct of pragmatic, EHR-embedded trials, the PEET program funds pilot demonstration projects. Requests for Applications (RFAs) are made available each year for 2-year pilot trials. Current priorities relate to studies conducted in adult populations within UCHealth.
The RFA describes eligibility and application requirements
Intent to Apply Opens December 2, 2025
If you have any questions about eligibility or the application please contact Sarah Kautz, PEET Program Coordinator.
Large-scale trials conducted in routine clinical care settings, involving:
Use of EHR systems to conduct pragmatic clinical trials to facilitate:
PEET Demonstration Project #1: A randomized, Pragmatic, Adaptive Trial of Metformin for Glucose Intolerance or Increased Body Mass Index in Prostate Cancer Patients (PragMet) (Principal Investigator: Thomas Flaig, MD) The goal of the study is to compare patients with prostate cancer who make changes in lifestyle with patients who make changes in lifestyle and also take a medicine called Metformin to reduce the risk of metabolic disorders.
PEET Demonstration Project #2: Optimizing Care in Critically ill at UCHealth by Liberalizing the Target O2 in mechanically-ventilated ICU patients (OCCULT O2) (Principal Investigators: Neil Aggarwal, MD and Peter Sottile, MD) The goal of the study is to significantly reduce the frequency of unrecognized or missed hypoxemia in patients who are mechanically ventilated in the ICU.
PEET Demonstration Project #3: ALERT-ED: Awareness and Linkage to Resources for At-Risk Emergency Department Patients (Principal Investigators: Elizabeth Goldberg MD, ScM and Jennifer Portz, MSW, PhD) The goal of the study is to use the EHR-based fall risk screening to identify high-risk emergency department patients and connect them with community programs to reduce falls and related ED revisits.
Neil Aggarwal, MD,MHSc is an Associate Professor in the Division of Allergy, Pulmonary, and Critical Care in the Department of Medicine at the University of Colorado, and Medical Director of the Progressive Care Unit in the Anschutz Medical Center. He is a federally-funded physician-scientist focused on improving outcomes in critical illness, including acute respiratory distress syndrome (ARDS), pneumonia, and sepsis. His group focuses on discovery of clinical and biological heterogeneity and precision-based therapies using pragmatic and innovative trial designs. He has significant experience in single- or multi-center clinical studies, and is currently a lead investigator in several NIH-funded networks focused on improving outcomes for critically ill adult patients.
Bethany Kwan, PhD, MSPH is Professor and Associate Vice Chair for Research in the Department of Emergency Medicine at the University of Colorado School of Medicine, Anschutz Medical Campus. As an investigator in the University of Colorado’s Adult & Child Center for Outcomes Research and Delivery Science (ACCORDS), she conducts pragmatic, patient-centered research and evaluation on health and health care in a variety of areas. With an emphasis on stakeholder engagement and dissemination and implementation (D&I) methods, her work addresses the integration of physical and behavioral health, chronic disease self-management, improving processes and systems of care to achieve the Quadruple Aim, pragmatic trials using electronic health data, and enhancing quality of life for patients and care partners. She works with patients and other stakeholders at all phases of research, from prioritization, to design, implementation, and dissemination of research. She mentors and teaches students, trainees, and fellow faculty on Designing for Dissemination to ensure that research innovations are efficiently and effectively adopted, used, and sustained in real world settings to improve health and well-being for all. Dr. Kwan is a member of the ACCORDS D&I program and directs the Colorado Clinical & Translational Sciences Institute (CCTSI) Dissemination & Implementation Research Core.
Lindsay Lennox, MA, is a Research Scientist in the Department of Emergency Medicine, and serves as PEET’s Program Manager. They’ve worked at the University of Colorado in communication, dissemination, technology transfer and research translation roles since 2006. In addition to leading overall project planning for PEET, they work to ensure coordination and alignment with other CU and CCTSI pragmatic research initiatives.
Sarah V. Kautz, PhD, LCSW, is the Program Coordinator for PEET. She earned her doctorate in clinical social work from the Institute of Clinical Social Work. She has worked in program evaluation for more than five years. Her research interests include interventions for children and families and chronic diseases.
Shelby West, MPH is a Program Coordinator for PEET. She earned her Master of Public Health degree in Epidemiology from the University of Alabama at Birmingham. Her research interests include infectious disease, social determinants of health, and how the built environment influences health outcomes.
2026 Key Dates |
RFA Posted
November 17, 2025 Intent to Apply OpensDecember 2, 2025 Intent to Apply DueDecember 16, 2025 by 11:59 PM MT Informational Call #1December 4, 2025 at 10:30 AM MT Email Sarah Kautz to register for this informational call Informational Call #2January 12, 2026 at 2:30 PM MT Email Sarah Kautz to register for this informational call Application OpenJanuary 13, 2026 Applications DueFebruary 9, 2026 by 11:59 PM MT Notice of SelectionMid to late June 2026 Award Start DateAugust 1, 2026 |
Contact Us |
Bethany Kwan, PhD, MSPH Director of CCTSI Pragmatic Trials Navigation Service 303-724-5153 Follow @bethanykwan View profile |
Lindsay Lennox, MA Program Manager, CCTSI Pragmatic Trials Navigation Service View Profile |
Sarah Kautz, PhD
Program Coordinator, Pragmatic EHR-Embedded Trials |