The TM-Pilot Program (formerly known as Novel Method Development) supports the development of novel methods and innovative technologies for clinical and translational research. This includes the development of new assays, methods or technologies which are not currently available to the CU Anschutz campus and CCTSI affiliated institutions.
Applications with two co-PIs, one for technology development and another for a scientific application, are especially encouraged to ensure future application and dissemination of newly developed technologies.
The TM-Pilot Request for Funding (RFA) is issued in October, applications due in December, and awards are selected in February. The active funding period is May through April. Exact dates are listed in the Key Dates section of this page.
Multiple TM-Pilot awards of up to $20,000 each will be awarded in these categories:
The RFA describes eligibility, award categories and application requirements.
Selection notices are sent by February following the application and review cycle, and Principal Investigators have through May to complete all Pre-Award Pilot Program and Regulatory requirements. Awards cannot be issued until documentation of all required approvals is received by the CCTSI Pilot Program Office.
CU-Denver PIs are not required to obtain approval (“routing”) from the Office of Grants and Contracts prior to application or award. PIs from affiliate organizations may be required to complete internal review processes at their organization prior to application (notably CSU) or award (notably CU-Boulder).
Technology Transfer Office (TTO)
Public disclosure, either in text or verbal form, may result in a lost opportunity to protect and commercialize your invention. All Principal Investigators of all funded CCTSI Pilot Grant Awards must connect with the CU Innovations Office (303-724-0221) for a consultation prior to receiving funds. In the event that a patent does arise from a funded project, it is imperative that CCTSI support is acknowledged (see “Citing CCTSI Funding” below).
For CSU Investigators
CSU investigators must complete the institutional proposal review process prior to submission, which includes review by the CVMBS college office and Office of Sponsored Programs Research Administrator, Julie Harvey. A signed proposal transmission letter from the CSU Office of Sponsored Programs (OSP) is required to be submitted with the Pilot Award application. Please contact Aimee Oke at for details.
PIs must obtain research approval from appropriate review bodies, such as COMIRB, IACUC, Biosafety, IBC, Children’s Hospital Research Institute, or any other regulatory group relevant to their project.
If a project will use CTRC resources, PIs must obtain Scientific Advisory and Review Committee (SARC) approval. CTRC resources include inpatient/outpatient research facilities, clinical research nursing support, nutrition research support, exercise research laboratory, ancillary funds; and CTRC Core Lab support.
Applications selected for award that include Human Subjects or Vertebrate Animal Research MAY require Prior Approval before award by the CCTSI funding agency, National Center for Advancing Translational Sciences (NCATS). At time of selection for award, the CCTSI will request information regarding your Human Subjects and Vertebrate Animal Research to ascertain specific required documentation for your project to submit for NCATS Prior Approval.
NCATS Prior Approval Documents may include: exempt certification, PI Biosketch, complete clinical research protocol, informed consent and assent forms, information on portion of any parent protocol supporting pilot or KL2 funding with explanation of exactly what aspects of that parent protocol are related to the pilot or KL2 project, IND or IDE documentation, an NIH-style “Protection of Human Subjects” section, an NIH-style “Vertebrate Animals” section, Inclusion Plan for Women, Children and Minorities, Targeted Enrollment Table or Inclusion Data Record, Data and Safety Monitoring Plan, Education Certification for Protection of Human Subjects, IRB Approval, and IACUC Approval.
PIs must report monthly during the Pre-Award period to the CCTSI Pilot Grant Program Coordinator, Debra Szuster regarding progress toward completion of all Pilot Program and Regulatory requirements.
Once all required Pre-Award activities are complete, the CCTSI Pilot Program Office will issue funding accounts to the PI in the official Notice of Award.
The active award period for TM-Pilot projects is May 1 through April 30. PIs are strongly encouraged to complete their projects within the original one-year active award period. No-Cost-Extensions (NCEs) are granted on a very limited basis for extraordinary circumstances and may not be allowed on all programs.
PIs must spend awards on direct costs related to achievement of specific aims outlined in the pilot project application. PIs must retain sufficient documentation of all expenses to justify any audit requests made of the CCTSI specific to the project. Unallowable expenses include (but are not limited to): international entities, computers, telecommunications, food, furniture, administrative support, non-project specific office expenses, and professional society dues/fees. Indirect costs are assessed internally by CCTSI and do not need to be included in your budget proposal, with the exception of proposals submitted by Colorado State University. CSU proposals should include Indirect costs at their federally negotiated rate. This will be in addition to the $20,000 direct cost budget.
PIs must respond to requests for interim progress reporting during the active phase of a project. This reporting is minimal and aimed at progress (% completion) relevant to specific aims.
All financial transactions must be posted within 30 days of the end date of the project. PIs must submit a final summary of the project’s impact within 30 days of request from the CCTSI. This web-based form will collect detailed information about the project. Upon submission of final summary and posting of final financial transactions, the CCTSI Pilot Program Office will complete audit and closeout procedures for the project.
PIs must complete evaluation and tracking requirements for 3 years after award. The CCTSI, as a component of its ongoing NIH support, is required to submit a detailed annual progress report that includes all funded pilot projects. In January of each year, PIs will be asked for brief information on publications and follow-on funding resulting from pilot projects. Prompt cooperation in providing the required information is expected.
Please refer to the How to Cite our CCTSI Grant for all publications, patents, or other tangible outcomes from this
project during and after project completion.
Affiliate home organizations may require applicants to complete an internal review process prior to submission. Applicants should check with their institutional grants or sponsored projects office to ascertain if their institution has pre-submission requirements for programs related to non-federal internally funded seed grant programs. Any awarded projects that have not met these requirements prior to submission will not be activated until all such affiliate institutional requirements are met.
Applications do not require official pre-award review (routing) through the CU Denver Office of Grants and Contracts (OGC) prior to submission.
CSU investigators must complete the institutional proposal review process prior to submission, which includes review by the CVMBS college office and Office of Sponsored Programs Research Administrator, Julie Harvey. A signed proposal transmission letter from the CSU Office of Sponsored Programs (OSP) is required to be submitted with the Pilot Award application. Please contact Aimee Oke for details.
You are required to complete an internal review process prior to receiving an award, but no prior approval for applying is required.
Regulatory approvals are not required at the time of application. All approvals/exemptions from appropriate review bodies or regulatory groups must be provided by the PI prior to the release of funds. This includes, but is not limited to: COMIRB, IACUC, Biosafety, IBC, Children’s Hospital Research Institute (CHRI), CSU IRB, and/or other regulatory groups relevant to the proposal and applicant’s institution.
If a funded proposal involves human subject research (HSR) and/or vertebrate animal research (VAR), The PI must provide an institutionally approved IRB protocol prior to the start of funding. Some funded HSR/VAR projects will require additional documentation for the NCATS Prior-Approval process; the CCTSI Pilot Grant Program Coordinator, Debra Szuster, will work with awardees on a case-by-case basis to submit required documentation. Applicants are strongly encouraged to demonstrate capacity to obtain regulatory approvals as soon as possible upon notification of selection for award.
PIs are required to obtain Scientific Advisory and Review Committee (SARC) approval for all projects using CTRC resources (inpatient/outpatient research facilities, clinical research nursing support, nutrition research support, exercise research laboratory, and CTRC Core Lab support).
Public disclosure, either in text or verbal form, may result in a lost opportunity to protect and commercialize your invention. All Principal Investigators of all funded CCTSI Pilot Grant Awards must connect with the CU Innovations Office (303-724-0221) for a consultation prior to receiving funds.
Intent-to-Apply and Application may only be submitted online via the TM-Pilot webpage. If an applicant intends to apply for funding for multiple projects, then each project must be submitted separately online. All submissions will be time-stamped. Submissions received after the 5pm MDT deadline will not be accepted. This program does not utilize an invitation process; however, only applicants who submit a mandatory Intent-to-Apply are eligible to submit an Application.
The mandatory online Intent-to-Apply Form collects minimal information via an online survey. The Intent-to-Apply is not binding, and information may be revised by applicants during the application process. Submission of your Intent-to-Apply Form will automatically generate an email confirmation with a PDF of your submission.
The online Application Form collects detailed information about the project via an online survey. The Application Form can be accessed via the “Survey Queue” after submitting the mandatory Intent-to-Apply Form. The online system will allow you to save, exit, return, review, and revise your submission as often as you wish using the “Save and Return Later” function up until the 5pm MDT submission deadline. Submission of the Application will generate a confirmation email.
If you have any questions about using the CCTSI online submission system, you can contact Debra Szuster for assistance.
Peer Reviewers with appropriate expertise will evaluate eligible applications with a specific emphasis on research that furthers the CCTSI mission. All Review Panel Study Sections are chaired by CCTSI Pilot Program Director(s) or Chair(s), and funding recommendations are presented to the CCTSI Executive Committee for approval. All Executive Committee decisions are final. Short informative critiques of application strengths and weaknesses are provided to all applicants after Notice of Selection for Awards are announced.
The six areas that are scored for each application include:
Innovation: Is the proposal innovative and novel in developing new technologies/assays/models? Are the proposed technologies presently not available to CCTSI members? Will the novel technologies enhance science and potential NIH proposals in the future?
Approach/Scientific Merit: Will the proposed study design achieve the aims of developing a new method or technology? What is the likelihood of success given the experiments/proposal as outlined? How feasible is the proposed one-year time frame to successfully develop the proposed technology? Are alternative approaches presented? Are there explicit plans for development of future funding for the project, whether from the NIH, foundations, or commercial sources?
Significance (especially to the CCTSI mission): Can the new method or technology be generalized and translated to other scientific settings/ applications? Are the technologies translational in their nature? Will the results further our understanding, diagnosis, prevention, and/or treatment of human disease?
Investigators: Do the investigators have the necessary expertise and capacity to complete the proposed research? is all necessary technological expertise present?
Environment: Does the research environment improve the likelihood that the proposed research can be completed and have an impact? Does the proposal consider use of CCTSI resources, including Study Design, Biostatistics, CTRCs, Core laboratories, Bionutrition core, etc?
Responsiveness to the CCTSI Educational Mission: Does the proposal explain how the technology will be disseminated among the CCTSI members (giving workshops, collaborating with Shared Resources)? Are students and fellows are involved in the project?
October 7, 2019
Meeting ID: 931 927 4660
November 13, 1:00 - 2:00 pm MST
Mandatory Intent-to-Apply Form (LOI)
Application Review Period
Notice of Selection
Project Funding Period