Colorado Pilot Program (CO-Pilot)

Past Awards

The Colorado Clinical and Translational Sciences Institute (CCTSI) is pleased to announce the CCTSI Pilot Grant Awardees for the Colorado Pilot (CO-Pilot) program. Congratulations to the awardees of the grants in this program.

2021 CO-Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Josiane Broussard, PhD
Kristen Boyle, PhD
Colorado State University
College of Health and Human Sciences
CU Anschutz Medical Campus
CU School of Medicine
Impact of weight loss on the intrinsic circadian clock in human skeletal muscle
Nalu Navarro-Alvarez, MD, PhDCU Anschutz Medical Campus
CU School of Medicine
The role of Galectin-3 in liver regeneration
Katharine Hamlington Smith, PhDCU Anschutz Medical Campus
CU School of Medicine
Using Oscillometry in Toddler Aerodigestive Patients to Monitor Lung Function Response to Treatment
Joseph Hippensteel, MDCU Anschutz Medical Campus
CU School of Medicine
Development of a Pre-Clinical Murine Model of Sepsis-associated Delirium
Allison Shapiro, PhDCU Anschutz Medical Campus
CU School of Medicine
Implementation of a novel, interdisciplinary protocol to study the pancreatic-hypothalamic axis in vivo in human adults
Allison Shapiro, PhDCU Anschutz Medical Campus
CU School of Medicine
Implementation of a novel, interdisciplinary protocol to study the pancreatic-hypothalamic axis in vivo in human adults
Joshua Bear, MDCU Anschutz Medical Campus
Children’s Hospital Colorado
CU School of Medicine
Spike-Associated Networks Predict Seizure Freedom after Epilepsy Surgery
Erin Englund, PhDCU Anschutz Medical Campus
CU School of Medicine
Evaluating the peripheral vascular blood flow and oxygenation responses to exercise in type 2 diabetes with time-resolved, quantitative MRI
Joshua Gowin, PhDCU Anschutz Medical Campus
CU School of Medicine
Mu opioid antagonism in reward circuity: effects on alcohol motivation
Shu-Yi Liao, MD, MPH, ScDNational Jewish Hospital
CU Anschutz Medical Campus
CU School of Medicine
A multi-Omics approach to determine the susceptibility, treatment effects, and progression of sarcoidosis
Sarah Purcell, PhDCU Anschutz Medical Campus
CU School of Medicine
Evaluating the impact of acute resistance exercise on appetite regulation in breast cancer survivors with loss of gonadal function
Alicia Rizzo, MD, PhDDenver Health
CU Anschutz Medical Campus
CU School of Medicine
ARDS endotyping via analysis of glycocalyx fragments in exhaled breath
Stephanie Gilley, MD, PhDCU Anschutz Medical Campus
CU School of Medicine
Early Iron Exposure on the Gut Microbiota in Young Infants
Maureen Banach, PhDCU Anschutz Medical Campus
CU School of Medicine
Properties of SARS-CoV-2-specific B cells and antibodies derived from convalescent COVID-19 patients
Brecca Gaffney, PhDCU Denver (Downtown Campus)
College of Engineering, Design, and Computing
Hip Morphological and Biochemical Changes after Long-Term Prosthesis Use
Alexa Spittler, DVM, MSColorado State University College of Veterinary Medicine and Biomedical SciencesEfficacy of Cannabidiol in a Murine Model of Post-traumatic Osteoarthritis

2020 CO-Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Kelly Doran, PhDPhD CU Anschutz Medical Campus
CU School of Medicine
Department of Immunology and Microbiology
Implications of Zinc Deficiency on Vaginal Microbiome Health and Perinatal Bacterial Infections
Jessica Metcalf, PhDColorado State University
College of Agricultural Sciences, Department of Animal Sciences
Dawn Duval, PhDColorado State University
College of Veterinary Medicine & Biomedical Sciences
Department of Clinical Sciences
Development of a comparative oncology functional genomics screening platform using a CRISPR-Cas9 library to identify critical dependencies and mechanisms of treatment resistance in canine cancers
James Costello, PhDCU Anschutz Medical Campus
CU School of Medicine
Department of Pharmacology
Seonil Kim, PhDColorado State University
College of Veterinary Medicine & Biomedical Sciences
Department of Biomedical Sciences
Beta amyloid-induced hippocampal network dysfunction via selective inhibition of nicotinic acetylcholine receptors in interneurons
Won Chan Oh, PhDCU Anschutz Medical Campus
CU School of Medicine
Department of Pharmacology
Dae Won Park, PhDCU Anschutz Medical Campus & CU Denver College of Engineering, Design and Computing
Department of Bioengineering
Engineered nanoparticles towards retinal ganglion cell axon regeneration and visual function recovery
Jozsef Vigh, PhDColorado State University
College of Veterinary Medicine & Biomedical Sciences
Department of Biomedical Sciences
Christopher Depner, PhDUniversity of Colorado Boulder
Department of Integrative Physiology
Sleep and Chronobiology Laboratory
Linking Sleep Health with Risk of Metabolic Disorders: A Machine Learning Approach
Evgenia Dobrinskikh, PhDCU Anschutz Medical Campus
CU School of Medicine
Department of Medicine
Division of Pulmonary Sciences
MUC5B in the Genesis of the Lung IPF Honeycomb Cyst
Chelsea Magin, PhDCU Anschutz Medical Campus
CU School of Medicine
Departments of Medicine and Bioengineering
Division of Pulmonary Sciences & Critical Care Medicine
Mechanically Tunable Hydrogel Biomaterials to Improve In Vitro Models of Pulmonary Fibrosis
Natalie Nokoff, MDChildren’s Hospital Colorado
CU School of Medicine, Department of Pediatrics
Division of Endocrinology
The effects of hormone therapy on renal hemodynamic function in transgender youth
Corey Rynders, PhDCU Anschutz Medical Campus
CU School of Medicine
Department of Medicine
Division of Geriatric Medicine
Entrainment of metabolic rhythms to the timing of energy intake
Celine Vetter, PhDUniversity of Colorado Boulder
Department of Integrative Physiology
Circadian and Sleep Epidemiology Lab
The Pathways Pilot Study - Pathways from Shift Work to Type 2 Diabetes Risk
Zachary L. Watson, PhDCU Anschutz Medical Campus
CU School of Medicine
Department of Obstetrics & Gynecology
Division of Reproductive Sciences
Revealing the roles of bone marrow-derived adipocytes in ovarian cancer progression
Vienna Brunt, PhDUniversity of Colorado Boulder
Department of Integrative Physiology
Integrative Physiology of Aging Lab
The Short-Chain Fatty Acid Acetate for Improving Age-Associated Arterial Dysfunction
Cristy Geno Rasmussen, MPH, PhDBarbara Davis Center for Diabetes
Division of Clinical Epidemiology
CU Anschutz Medical Campus
CU School of Medicine, Department of Pediatrics
Psychosocial Health in Adults with Type 1 Diabetes: A Pilot & Feasibility Study
Sarah Gitomer, MDChildren’s Hospital Colorado
CU School of Medicine
Department of Otolaryngology
Division of Pediatric Otolaryngology
Early identification and mitigation of hearing loss associated with bacterial meningitis in children
Jesse Hinckley, MD, PhDCU Anschutz Medical Campus
CU School of Medicine
Department of Psychiatry
Division of Substance Dependence
Characterization of endocannabinoid and endogenous opioid levels in adolescents with cannabis use disorder
Hollis Karoly, PhDColorado State University
College of Natural Sciences
Department of Psychology
Divisions of Cognitive Neuroscience and Counseling Psychology 
Exploring the Effects of Acute Cannabidiol Administration on Blood Alcohol Level and Intoxication in Adult Human Subjects
Carolina Mehaffy, PhDColorado State University
College of Veterinary Medicine & Biomedical Sciences
Department of Microbiology, Immunology and Pathology
Development of a chemiluminescent ELISA for the detection of Mycobacterium tuberculosis proteins in host serum exosomes and diagnosis of Latent TB Infection
Dori Miller, PhDCU Anschutz Medical Campus
CU School of Medicine
Department of Medicine
Division of Geriatrics
Impact of Estrogens on Adipogenesis
Prakruti Patel, PT, PhDColorado State University
College of Health and Human Sciences
Movement Neuroscience and Rehabilitation Laboratory
Functional Consequence and Mechanisms of Impaired Bilateral Gait Coordination after Stroke
Jenna Yager, PharmDCU Anschutz Medical Campus
CU School of Pharmacy
Department of Pharmaceutical Sciences
HIV outpatient monitoring evaluation (HOME) through self-collection of dried blood spots (DBS

2019 CO-Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Ramesh Akkina, DVM, PhDColorado State University
College of Veterinary Medicine and Biomedical Sciences
Microbiology, Immunology and Pathology
Modeling Zika Virus Pathogenesis In Humanized Mice
David Beckham,  MDCU Denver Anschutz Medical Campus
School of Medicine
Department of Medicine
Division of Infectious Diseases
 
Mary-Keara Boss, DVM, PhDColorado State University
College of Veterinary Medicine and Biomedical Sciences
Environmental and Radiological Health Sciences
Impact Of Regional Lymph Node Irradiation On The Anti-Tumor Immune Response For Patients With Advanced Head And Neck Cancer
Sana Karam PhD, MDCU Denver Anschutz Medical Campus
Department of Radiation Oncology
 
William Cornwell, MDCU Denver Anschutz Medical Campus
School of Medicine
Department of Medicine
Division of Cardiology
New Insights Into Right Ventricular Performance In Health And Disease Using High-Fidelity Conductance Catheters To Generate Real-Time Pressure-Volume Loops At Rest And With Exercise
Christine Swanson,  MD MCRCU Denver Anschutz Medical Campus
School of Medicine
Department of Internal Medicine
Division of Endocrinology, Metabolism and Diabetes
The Effects Of Insufficient Sleep On Bone Metabolism
Vera Fridman,  MDCU Denver Anschutz Medical Campus
School of Medicine
Department of Neurology
Role Of Atypical Sphingolipids In Diabetic Neuropathy 
Walter Knight,  PhDCU Denver Anschutz Medical Campus
School of Medicine
Department of Medicine
Division of Cardiology
High Throughput Screening For Novel Compounds For The Treatment Of Hypertrophic Cardiomyopathy Using Stem Cell Derived Cardiomyocytes
Katie Sikes,  PhDColorado State University
College of Veterinary Medicine and Biomedical Sciences
Department of Clinical Sciences
Orthopaedic Research Center
The Role Of Toll-Like Receptors In A Murine Model Of Tendinopathy
Simona Zarini,  PhDCU Denver Anschutz Medical Campus
School of Medicine
Department of Medicine
Division of Endocrinology, Metabolism & Diabetes
Exploring The Relationship Between Human Skeletal Muscle Deoxysphingolipid Accumulation And Insulin Resistance
Terry Fry,   MDCU Denver Anschutz Medical Campus
School of Medicine
Departments of Pediatrics, Hematology and Immunology
Robert and Kathleen Clark Endowed Chair in Pediatric Cancer Therapeutics
Children’s Hospital Colorado, Center for Cancer and Blood Disorders
Development Of Chimeric Antigen Receptor T Cell Immunotherapy For Canine Malignancies As A Platform For Testing Novel Human CAR Constructs
Doug Thamm,  VMD, DACVIMColorado State University
Barbara Cox Anthony Professor of Oncology
Director of Clinical Research
Flint Animal Cancer Center
 
Kasey Couts,  PhDCU Denver Anschutz Medical Campus
School of Medicine
Department of Medicine
Division of Medical Oncology
The Role Of BRAF Fusions In Melanoma Anti-Tumor Immune Responses
Maheen Abidi,  MDCU Denver Anschutz Medical Campus
School of Medicine
Department of Internal Medicine
Division of Infectious Disease
CMV Immune Monitoring Utilizing CMV-Specific Fluorospot Assay In High-Risk Hematopoietic Stem Cell Transplant Recipients Treated With Letermovir For CMV Prophylaxis
Susan Calcarterra,  MD, MPH, MSCU Denver Anschutz Medical Campus
School of Medicine
Department of Medicine
Division of Internal Medicine
Identifying Barriers To Providing Addiction Treatment For
Hospitalized Patient
Nicole Darling,  PhDCU Denver Anschutz Medical Campus
School of Medicine
Department of Medicine
Division of Pulmonary Science and Critical Care
Mechanically Tunable Hydrogel Biomaterials To Improve Three-Dimensional (3D) Models Of Idiopathic Pulmonary Fibrosis (IPF)
Nikki Farnsworth,  PhD MS BSCU Denver Anschutz Medical Campus
School of Medicine
Department of Pediatrics
Barbara Davis Center for Childhood Diabetes
The Role Of Protein Kinase C Delta And Extracellular Matrix Interactions In Beta-Cell Decline In Type 1 Diabetes
Caroline Hall,  MD PhDChildren's Hospital Colorado
Division of Pediatric Gastroenterology, Hematology and Nutrition
Digestive Health Institute
Evaluation Of The Role Of Creatine Transporter And Creatine In Inflammatory Bowel Disease
Brad Haverkos,  MDCU Denver Anschutz Medical Campus
School of Medicine
Department of Medicine
Division of Hematology
Leveraging Immunotherapy To Improve Treatments For Newly Diagnosed Peripheral T-Cell Lymphomas
Laura Sole Codina,  PhD MS BAColorado State University
College of Veterinary Medicine and Biomedical Sciences
Department of Biomedical Sciences
Molecular Physiology Of Nav1.6 Epileptic Encephalopathy Mutations: Analysis Of Channel Function And Trafficking
Xiaoqiao Xie,  PhD MS BSCU Denver Anschutz Medical Campus
School of Medicine
Department of Surgery
Division of Urology
Beyond The Neurons: The Role Of Peripheral Glia In Neurogenic Bladder Dysfunction
Shuo Zhou,  PhDCU Denver Anschutz Medical Campus
Colorado School of Public Health
Department of Community & Behavioral Health
Using Virtual Reality To Assess The Influence Of Environmental Smoking Cues On Craving Among Smokers

2018 CO-Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Melanie Joy, PharmD, PhDDepartment of Pharmaceutical Sciences
Skaggs School of Pharmacy
CU Denver - Anschutz Medical Campus
Medical Device for Kidney Disease Indication: From Canines to Humans
Geoff Heffner, DVMColorado State University
Veterinary Teaching Hospital
 
Karen King, PhDDivision of Research
Department of Orthopedics
School of Medicine
CU Denver - Anschutz Medical Campus
Improving bone repair in the presence of diabetes
Nicole Ehrhart, VMD, MS, Diplomate ACVSColorado State University
School of Biomedical Engineering
Department of Clinical Sciences
Division of Surgical Oncology
 
Tiffany Weir, PhDColorado State University
Department of Food Science and Human Nutrition
Exploring a Novel Role for the Gut Microbiota and Intestinal Inflammation in Obesity-Related Vascular Dysfunction
Chris Gentile, PhDColorado State University
Department of Food Science and Human Nutrition
 
Sean Colgan, PhDDivision of Gastroenterology
Department of Medicine
School of Medicine
CU Denver - Anschutz Medical Campus
 
Audrey Bergouignan, PhDDivision of Endocrinology
Department of Medicine
School of Medicine
CU Denver - Anschutz Medical Campus
Effect of frequent interruptions of sedentary time on glucose homeostasis in free living pre-diabetic overweight adults
Melanie Cree-Green, MD, PhDDivision of Endocrinology
Department of Pediatrics
School of Medicine
CU Denver - Anschutz Medical Campus
Do alterations in serum testosterone mediate systemic insulin sensitivity and hepatic health via the gut microbiota?
Anna Jovanovich, MDDivision of Renal Diseases and Hypertension
Department of Medicine
School of Medicine
CU Denver - Anschutz Medical Campus
Changes in Vascular Function after Acute Kidney Injury
Kristina Legget, PhDDepartment of Psychiatry
School of Medicine
CU Denver - Anschutz Medical Campus
Effects of exercise on brain functional connectivity deficits in autism spectrum disorders
Kristen Nowak, PhD, MPHDivision of Renal Diseases and Hypertension
Department of Medicine
School of Medicine
CU Denver - Anschutz Medical Campus
Daily Caloric Restriction and Intermittent Fasting in Overweight and Obese Adults with Autosomal Dominant Polycystic Kidney Disease
Daniel Sherbenou, MD, PhDDivision of Hematology
Department of Medicine
School of Medicine
CU Denver - Anschutz Medical Campus
Ex Vivo Drug Resistance Screening to Personalize Treatment in Multiple Myeloma
Elizabeth Thomas, MDDivision of Endocrinology, Diabetes and Metabolism
Department of Medicine
School of Medicine
CU Denver - Anschutz Medical Campus
Pilot study of time restricted feeding as a weight loss intervention in adults with overweight and obesity
Kolene E. Bailey, MDDivision of Pulmonary Sciences and Critical Care
Department of Medicine
School of Medicine
CU Denver - Anschutz Medical Campus
Bioengineered Hydrogels to Improve Three-Dimensional (3D) Models of Lung Regeneration in Chronic Obstructive Pulmonary Disease (COPD)
Petter Bjornstad, MDDivision of Endocrinology
Department of Pediatrics
School of Medicine
CU Denver - Anschutz Medical Campus
Impact of Bariatric Surgery on intrarenal hemodynamic function in obese adolescents with type 2 diabetes
Josiane Broussard, PhDDepartment of Integrative Physiology
CU Boulder
Impact of insufficient sleep on adipose and skeletal muscle tissue
Sarah Clark, PhDDepartment of Immunology and Microbiology
School of Medicine
CU Denver - Anschutz Medical Campus
Pulmonary Immune Suppression by Bacterial-Derived Products
Jordan Hoffman, MPH, MDDivision of Cardiothoracic Surgery
Department of Surgery
School of Medicine
CU Denver - Anschutz Medical Campus
Evaluation of Right Ventricular Performance in Patients undergoing Left Ventricular Assist Device Implantation
Michael Kriss, MDDivision of Gastroenterology & Hepatology
Department of Medicine
School of Medicine
CU Denver - Anschutz Medical Campus
A novel translational model to define the relationship between gut-bacteria derived butyrate, hepatic innate immunity, and early allograft outcomes following living donor liver transplant
Matthew D. McGraw, MDDivision of Pulmonology
Department of Pediatrics
School of Medicine
CU Denver - Anschutz Medical Campus
Airway Epithelial ‘Stem Cells’ for Bronchiolitis Obliterans
Richard Tobin, PhDDivision of Surgical Oncology
Department of Surgery
School of Medicine
CU Denver - Anschutz Medical Campus
Determining the role of mucosal-associated invariant T (MAIT) cells in gut microbiome-associated clinical responses to anti-PD1 therapy in melanoma patients

2017 CO-Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Lori Walker, PhDDivision of Cardiology
Department of Medicine
School of Medicine
CU Denver - Anschutz Medical Campus
Cardiovascular Risks of Marijuana
Christine Tompkins, MDDivision of Cardiology
Department of Medicine
School of Medicine
CU Denver - Anschutz Medical Campus
Cardiovascular Risks of Marijuana
David Kao, MD, PhDDivision of Cardiology
Department of Medicine
School of Medicine
CU Denver - Anschutz Medical Campus
Cardiovascular Risks of Marijuana
Rui Zhao, PhDDepartment of Biochemistry and Molecular Genetics
School of Medicine
CU Denver-Anschutz Medical Campus
Targeting splicing factor U2AF35 for ovarian cancer therapy
Susan LaRue, DVM, PhD (CSU)Department of Environmental and Radiological Health Sciences
Colorado State University
Therapeutic intervention of radiation-induced dermatitis for canine cancers treated with radiation therapy
Xiao-Jing Wang, MD, PhD (UCD)Department of Pathology
School of Medicine
CU Denver-Anschutz Medical Campus
 
Indrajit Ray, PhD (CSU)Department of Computer Science
College of Natural Sciences
Colorado State University
Novel Protocols for Anonymous Patient De-duplication in Regional Data Networks for Accurate Cohort Identification
Toan Ong, PhD (UCD)Department of Pediatrics
School of Medicine
CU Denver-Anschutz Medical Campus
 
Colm Collins, PhDDivision of Gastroenterology, Hepatology & Nutrition
Department of Pediatrics
School of Medicine
CU Denver - Anschutz Medical Campus
High Risk; Cannabis use to alleviate symptoms of intestinal inflammation
Mustafa Ozkaynak, PhDCollege of Nursing
CU Denver - Anschutz Medical Campus
Developing a predictive model for optimal discharge decision for asthma patients in pediatric EDs
Sangeeta Rao, BVSc, MVSc, PhDDivision of Epidemiology
Department of Clinical Sciences
College of Veterinary Medicine & Biomedical Sciences
Colorado State University
Rapid detection and profiling of antimicrobial resistance in Staphylococcus and Salmonella human infections: A novel application using MALDI-TOF Mass Spectrometry
Neera Tewari-Singh, PhDDivision of Toxicology
Department of Pharmaceutical Sciences
Skaggs School of Pharmacy and Pharmaceutical Sciences
CU Denver - Anschutz Medical Campus
Therapeutic Strategy for corneal healing in diabetic and non-diabetic dry eye models
Courtney Jones, PhDDivision of Hematology
Department of Medicine
School of Medicine
CU Denver - Anschutz Medical Campus
Targeting Metabolic Vulnerabilities of Leukemia Stem Cells
Brice McConnell, MD, PhDDepartment of Neurology
School of Medicine
CU Denver - Anschutz Medical Campus
Application of Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance in
Patients with Mild Cognitive Impairment

2016 CO-Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Richard Vandivier, MDDivision of Pulmonology
Department of Medicine
School of Medicine
CU Denver - Anschutz Medical Campus
Targeting Steroid Resistance During Acute Exacerbations of COPD with Respiratory Failure -The AECOPD Resistance Study
Chang-Wei Liu, PhDDepartment of Biochemistry and Molecular Genetics
School of Medicine
CU Denver-Anschutz Medical Campus
Identifying leading chemical compounds that inhibit a deubiquitinating enzyme for anti-cancer drug development
Dohun Pyeon, PhDDepartment of Immunology and Microbiology
School of Medicine
CU Denver-Anschutz Medical Campus
Developing a Novel Antitumor Immunotherapy by Chemokine Modulation
Peter Sottile, MDDivision of Pulmonary Sciences and Critical Care
Department of Medicine
School of Medicine
CU Denver - Anschutz Medical Campus
Development of a Computerized Algorithm to Detect and Assess the Association between Ventilator Dyssynchrony and Sedation
Donald Beqollari, PhDDivision of Cardiology
Department of Medicine
School of Medicine
CU Denver - Anschutz Medical Campus
Sex differences in skeletal muscle ageing
Kristy Howell, PhDDepartment of Psychiatry
School of Medicine
CU Denver - Anschutz Medical Campus
Gene-Environment interactions underlying neurodevelopmental disorders: Examining the impact of obstetric complications on the placenta, AKT1, brain development and function
Michael Regner, MDDivision of Neuroradiology
Department of Radiology
School of Medicine
CU Denver - Anschutz Medical Campus
Insular inhibitory neuromodulation to reduce cigarette craving and alter brain function in smokers
Kerstin Pohl, PhDDivision of Pulmonology
Department of Medicine
National Jewish Health
CFTR modulation restores Mycobacterium abscessus killing by neutrophils in cystic fibrosis
Kasey Couts, PhDDivision of Medical Oncology
Department of Medicine
School of Medicine
CU Denver - Anschutz Medical Campus
 
Jesse Wilson, PhD Department of Electrical and Computer Engineering
School of Biomedical Engineering
Colorado State University
Low-cost platform for in vivo, noninvasive melanoma and pigmented lesion histopathology, combining transient
absorption laser microscopy and digital signal processing

2015 CO-Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Thomas Campbell, MDDivision of Infectious Diseases
Department of Medicine
School of Medicine
CU Denver Anschutz Medical Campus
Genetic associations with Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus
James DeGregori, PhDDepartment of Biochemistry and Molecular Genetics
School of Medicine and UCCC
CU Denver Anschutz Medical Campus
Analyzing changes in human hematopoietic mutational landscapes with age
Benzi Kluger, MD MSDivision of Movement Disorders
Department of Neurology
School of Medicine
CU Denver Anschutz Medical Campus
Rhythmic Enhancement of Motor Performance: Cortical Mechanisms in Healthy Older Adults and Parkinson's Disease
Maki Nakayama, MD PhDBarbara Davis Center
Department of Pediatrics
School of Medicine
CU Denver Anschutz Medical Campus
Identification of T cell Autoantigens Critical for the Development of Human Type 1 Diabetes
Jennifer Honda, PhDDivision of Pulmonary and Critical Care
Department of Medicine
School of Medicine
CU Denver Anschutz Medical Campus
Investigating the Pathogenesis of Nontuberculous Mycobacterial Lung Disease in Patients from Oahu, Hawaii
Suzhao Li, MD PhDDivision of Infectious Diseases
Department of Medicine
School of Medicine
CU Denver Anschutz Medical Campus
Mechanistic Study of IL-37 in Protecting Against Obesity Induced Inflammation and Insulin Resistance
Christopher Martens, PhDDepartment of Integrated Physiology
CU Boulder
Nicotinamide-Riboside Supplementation for Improving Physiological Function in Middle-Aged and Older Adults
Anita Quintana, PhDDepartment of Psychiatry
School of Medicine
CU Denver Anschutz Medical Campus
HCFC1 regulates brain development by modulating the expression of PHACTR4 in neural precursors
Lindsay Weitzel, PhDDepartment of Anesthesiology
School of Medicine
CU Denver Anschutz Medical Campus
The Role of the A2B Receptor in a Mouse Model of Stroke
Bryan Yunker, PhDDepartment of Bioengineering
College of Engineering and Applied Science
CU Denver Anschutz Medical Campus
Estimation of regional blood flow within a Region of Interest set within a 3D medical image volume by reconstructing vessel structure, including autonomous angle correction for 3D Color Doppler data sets 
Gagan Deep, PhDDepartment of Pharmaceutical Sciences
Skaggs School of Pharmacy and Pharmaceutical Sciences
CU Denver Anschutz Medical Campus
A novel strategy to target hypoxic cells in prostate tumor
Marcela Henao-Tamayo, MD PhDDepartment of Microbiology, Immunology and Pathology
Colorado State University
In vivo role of perilipin-2 and macrophage lipid metabolism in tuberculosis pathogenesis: mechanisms of induction,
treatment response and relapse
Rachael Van Pelt,  PhDDepartment of Medicine
Division of Geriatric Medicine
CU Denver Anschutz Medical Campus
Aging and Subcutaneous Adipose Tissue Response to Overfeeding

2014 CO-Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Karen King, PhDDepartment of Orthopaedics, School of Medicine, University of Colorado Denver | Anschutz Medical CampusDysregulation of phosphorus is the common denominator for age-related CKD, CVD, and renal osteodystrophy
Adit A. Ginde, MD, MPHDepartment of Emergency Medicine, School of Medicine, University of Colorado Denver | Anschutz Medical CampusProton Pump Inhibitors for Prevention of Septic Acute Kidney Injury
Sarah K. Parker, MDDepartment of Pediatrics, Division of Infection Diseases, School of Medicine, University of Colorado Denver | Anschutz Medical CampusPilot study of Metronidazole Pharmacokinetics in Pediatric Patients
Kathleen M. Gavin, PhDDepartment of Medicine, Division of Geriatric Medicine, School of Medicine, University of Colorado Denver | Anschutz Medical CampusMeasurement of Bone Marrow-derived Adipocytes in Humans
Traci R. Lyons, PhDDepartment of Medicine, Division of Medical Oncology, School of Medicine, University of Colorado Denver | Anschutz Medical CampusCharacterization of pro-lymphangiogenic molecules in postpartum breast cancers
Leah R. Villegas, PhDDepartment of Medicine, Division of Pediatrics/ Cardiovascular Pulmonary Research, School of Medicine, University of Colorado Denver | Anschutz Medical CampusTargeted Delivery of an Extracellular Superoxide Dismutase Biotherapeutic to the Pulmonary
Neil Box, PhDDepartment of Dermatology, School of Medicine, University of Colorado Denver | Anschutz Medical CampusChemoprevention of skin cancer – towards a better sunscreen
Isabel R. Schlaepfer, PhDDepartment of Pharmacology, School of Medicine, University of Colorado Denver | Anschutz Medical CampusPilot study to enhance 18F-FDG-PET imaging of human prostate cancer with ranolazine
Deborah Garrity, PhDDepartment of Biology, Colorado State UniversityCharacterization of zebrafish models of filamin C cardiomyopathy
Jill Litt, PhDDepartment of Environmental Health, Colorado School of Public Health, University of Colorado Denver | Anschutz Medical CampusChanging industries, landscapes, and environments: Implications for the public's health in Colorado

2013 CO-Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Christine Lin, MDMedicine/Pulmonary Sciences & Critical Care Medicine, University of Colorado Denver | Anschutz Medical CampusMechanisms of Antibody-Dependent Transplant Injury and Rejection
Jennifer Salstrom, MDDepartment of Biochemistry and Molecular Genetics, University of Colorado Denver | Anschutz Medical CampusIdentifying novel therapeutic targets for high risk FLT3-mutated Acute Myeloid Leukemia
Nicholas Walter, MDMedicine/Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver | Anschutz Medical CampusmicroRNA response to a emerging hyper-virulent M. tuberculosis lineage
Robert Doebele, MD, PhDDepartment of Medicine, Division of Medical Oncology, University of Colorado Denver | Anschutz Medical CampusNovel gene fusions as targets for NSCLC
Benzi Kluger, MD, Innovation in Translational Neuroscience AwardNeurology, University of Colorado Denver | Anschutz Medical CampusCortical Physiology as a Parkinson's Disease Biomarker
Maria Nagel, MD, Innovation in Translational Neuroscience AwardNeurology, University of Colorado Denver | Anschutz Medical CampusPurinergic signaling in VZV vasculopathy
Eric Schmidt, MDPulmonary Sciences and Critical Care Medicine, University of Colorado Denver | Anschutz Medical CampusHeparanase mediates sepsis-induced acute kidney injury
Hang (Hubert) Yin, PhDChemistry & Biochemistry, University of Colorado BoulderOptimizing Small Molecule Inhibitors of TLR3 as Potential Atherosclerosis Drug
Arthur Gutierrez-Hartmann, MDDepartments of Medicine and of Biochemistry & Molecular Genetics, Division of Endocrinology, University of Colorado Denver | Anschutz Medical CampusSilencing transcription factor ESE-1 in vivo with tumor-targeted sonoporation to treat breast cancer
Marcelo Sousa, PhDDepartment of Chemistry and Biochemistry, Division of Biochemistry,
University of Colorado Boulder
ArnA inhibitors to defeat Pseudomonas antibiotic resistance in Cystic Fibrosis
Kimberly Bjugstad, PhD, Collaborative Research in Translational Neuroscience AwardPediatrics/Genetics, University of Colorado Denver | Anschutz Medical CampusThe Key to Reversible Tau Phosphorylation and Neural Tissue Engineering Might Be Found in Hibernating Squirrels: A Look Towards Treating Alzheimer's Disease
Amy Brooks-Kayal, MD, Collaborative Research in Translational Neuroscience AwardPediatrics/Neurology, University of Colorado Denver | Anschutz Medical CampusDefining signaling pathway perturbations in epilepsy

 

2012 CO-Pilot Program Awards

Principal InvestigatorAffiliationProject Title
John Hartney, PhDImmunology, National Jewish HealthThromboxane receptor inhibition for COPD
Isabelle Buard, PhDDepartment of Psychiatry, University of Colorado Denver | Anschutz Medical CampusMultimodal neuroimaging of motor dysfunction in Autism Spectrum Disorders
Claudia Jakubzick, PhDDepartments of Pediatrics and Immunology, National Jewish HealthPulmonary CD103+ DCs are cross-presenting DCs required for cancer immunity.
Kathryn Chatfield, MD, PhDDepartment of Pediatrics, Division of Cardiology, University of Colorado Denver | Anschutz Medical CampusCardiolipin Metabolism in Pediatric Heart Failure
Amrut Ambardekar, MDDepartment of Medicine, Division of Cardiology, University of Colorado Denver | Anschutz Medical CampusLongitudinal Effects of Unloading with a Left Ventricular Assist Device on Myocyte Contractility and Left Ventricular Mechanics
Roger Bannister, PhDDepartment of Medicine, Division of Cardiology, University of Colorado Denver | Anschutz Medical CampusRGK proteins and ALS muscle
Marco Gonzalez, PhDDepartment of Pediatrics, Division of Neurology, University of Colorado Denver | Anschutz Medical CampusThe Role of Proteolysis in Epilepsy
Geeta Sharma, PhDDepartments of Cell & Developmental Biology and Physiology & Biophysics, University of Colorado Denver | Anschutz Medical CampusCholinergic modulation of neurogenesis in adult CNS
Sally Tarbell, PhDDepartment of Psychiatry, Division of Child & Adolescent Psychiatry, University of Colorado Denver | Anschutz Medical CampusAnxiety Risk in Youth with Cyclic Vomiting Syndrome: Threat Perception, Coping and Physiological Reactivity
Rui Zhao, PhDDepartment of Biochemistry and Molecular Genetics, University of Colorado Denver | Anschutz Medical CampusTargeting a transcriptional co-repressor CtBP for cancer therapy

2011 CO-Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Audrey Bergouignan, PhDPediatrics Department, School of Medicine, University of Colorado Denver | Anschutz Medical CampusA novel tracer method to understand the mechanisms of reduced dietary fat oxidation in obese and reduced-obese humans
Melanie Cree-Green, MD, PhDPediatrics Department, School of Medicine, University of Colorado Denver | Anschutz Medical CampusRole of androgens and obesity in insulin resistance and cardiovascular disease in polycystic ovarian disease
Jose Castillo-Mancilla, MDMedicine Department and Infectious Diseases Division, School of Medicine, University of Colorado Denver | Anschutz Medical CampusThe effect of CYP3A5, ABCB1 and SLCO1B1 polymorphisms on the metabolism of atazanavir in HIV-1 infected patients
Jennifer Taylor-Cousar, MDMedicine Department and Pulmonary/Critical Care Division, National Jewish HealthEffects of sildenafil on CFTR-dependent ion transport activity
Mark Rentschler, PhD, PEMechanical Engineering Department, University of Colorado BoulderGastrointestinal Tract Tissue Mechanics
Wenbo Zhou, PhDMedicine Department and Clinical Pharmacology and Toxicology Division, School of Medicine, University of Colorado Denver | Anschutz Medical CampusScreening drugs that may stop the progression of Parkinson’s disease
Bolin Liu, MDPathology, School of Medicine, University of Colorado Denver | Anschutz Medical CampusAbrogation of Herceptin-resistant breast cancer phenotype in in vivo tumor xenograft model
Greg Austin, MD, MPHClinical Pharmacy, School of Pharmacy, University of Colorado Denver | Anschutz Medical CampusGastrointestinal and Neuronal Responses to Meals as Mediators of Weight Loss and Weight Regain”
Matt Taylor, MD, PhDMedicine Department and Cardiology Division, School of Medicine, University of Colorado Denver | Anschutz Medical CampusWhole exome DNA sequencing for novel gene discovery in cardiomyopathy
Dan Feldheim, PhDChemistry and Biochemistry Department, University of Colorado BoulderA Rapid TB Diagnostic Assay For Resource-Poor Settings
Tim McKinsey, PhDMedicine Department and Cardiology Division, School of Medicine, University of Colorado Denver | Anschutz Medical CampusPre-Clinical Evaluation of an HDAC Inhibitor in a Model of Diastolic Heart Failure
Kurt Stenmark, MDPediatrics Department, School of Medicine, University of Colorado Denver | Anschutz Medical CampusA Systems Biology Approach to Pulmonary Vascular Disease: Integrating Vascular Stiffness with Cardiac Function and Microvascular Disease

2010 CO-Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Dr. Ellen EliasChildren's Hospital ColoradoInvestigating the Genetic Etiologies causing Autism Spectrum Disorder in Patients with Down Syndrome
Dr. Rocio PereiraEndocrinology Department, Endocrinology Division and Denver Health Community Health Service, School of Medicine, University of Colorado Denver | Anschutz Medical CampusAdiponectin as an Independent Determinant of Ethnic Differences in Insulin Resistance
Dr. Jeffrey OlsonOpthamology Department and Rocky Mountain Lions Eye Institute, School of Medicine, University of Colorado Denver | Anschutz Medical CampusNovel Intraocular Device for the Treatment of Diabetic Retinopathy
Dr. Russell BowlerMedicine Department and Pulmonary/Critical Care,  Medicine Division, National Jewish HealthThe role of CD4+ Regulatory and T17 Helper T Cells in Emphysema
Dr. Chris ColdrenDepartment of Medicine and Pulmonary/Critical Care Division, School of Medicine, University of Colorado Denver | Anschutz Medical CampusGenome-Wide Analysis of Private Copy Number Variation in Hypoplastic Left Heart Disease
Dr. Janine HigginsPediatrics Department and Center for Human Nutrition, School of Medicine, University of Colorado Denver | Anschutz Medical CampusOptimal Strategies For Weight Gain In Anorexia Nervosa: A Translational Approach
Dr. Timberley RoaneIntegrative Biology Department, College of Liberal Arts and Sciences, University of Colorado DenverMolecular Comparisons of Bacterial Microbiota Associated with Affected and Unaffected Skin of Children with Atopic Dermatitis
Dr. Linda WatkinsPsychology and Neuroscience Departments, College of Arts and Sciences, University of Colorado BoulderExploration of a novel microparticle-based gene therapy approach for treating diseases of the central nervous system
Dr. Barbara FrederickRadiation Oncology Department, School of Medicine, University of Colorado Denver | Anschutz Medical CampusEnhancement of radiation-induced DNA damage by PARP1 inhibition in the treatment of head and neck cancer
Dr. Judith GaultNeurosurgery and Psychiatry Departments, School of Medicine, University of Colorado Denver | Anschutz Medical CampusAntibody development for Antipsychotic Treatment-Response Biomarker of Psychosis
Dr. Magdalena GorskaMedicine Department, National Jewish HealthThe importance of the signaling protein Unc119 in Th2 responses in asthma
Dr. Stella HinesMedicine Department and Pulmonary/Critical Care Division, National Jewish HealthAssessment of Respiratory Health Effects and Immunologic Sensitivity in Epoxy Resin Workers
Dr. Lauren FreyNeurology Department, School of Medicine, University of Colorado Denver | Anschutz Medical CampusCysteinyl-leukotrienes and oxidative stress after experimental traumatic brain injury
Dr. Eric SchmidtMedicine Department, Denver HealthPlasma Biomarkers of endothelial glycocalyx injury in human sepsis and acute lung injury
Dr. Robert StearmanMedicine Department and Pulmonary Sciences/Critical Care Division, School of Medicine, University of Colorado Denver | Anschutz Medical CampusNext-Gen Sequencing of Targeted Genes in Familial Pulmonary Fibrosis
Dr. Aik-Choon TanMedical Oncology Department, School of Medicine, University of Colorado Denver | Anschutz Medical CampusDeveloping Circulating MicroRNA Signature to Guide Targeted Therapies in Cancer Treatment
Dr. Samuel ChangRadiology Department, School of Medicine, University of Colorado Denver | Anschutz Medical CampusDevelopment and Testing of a “Volumetric Color Doppler Vascular Index” to Predict the Performance of Radiofrequency Ablation Devices in Liver Tumors: Translational Study in an In-vitro Blood Perfused Bovine Liver Model
Dr. Marco GonzalezPediatrics Department, School of Medicine, University of Colorado Denver | Anschutz Medical CampusRegulation of GABA(A) Receptors After Status Epilepticus
Dr. Chien-Chi LinChemical and Biological Engineering Department, University of Colorado BoulderBiomaterial strategy to regulate local inflammation induced by the pro-inflammatory cytokines
Dr. Ryan MaysMedicine Department and Cardiology Division, School of Medicine, University of Colorado Denver | Anschutz Medical CampusA community-based exercise program for patients with claudication resulting from peripheral arterial disease
Dr. Eoin McNameeMedicine Department and Gastroenterology and Hepatology Division, School of Medicine, University of Colorado Denver | Anschutz Medical CampusLymphotoxin in Inflammatory Bowel Disease: Role in Pathogenesis and Therapeutic Target
Dr. Siranush SargsyanNeurology Department, School of Medicine, University of Colorado Denver | Anschutz Medical CampusThe role of recombinant multiple sclerosis antibodies in disease pathogenesis
Dr. Simon WaldbaumPharmaceutical Sciences Department, School of Pharmacy, University of Colorado Denver | Anschutz Medical CampusTargeting mitochondrial oxidative stress in epileptogenesis with a novel synthetic antioxidant
Dr. Nicholas WalterMedicine Department and Pulmonary/Critical Care Division, School of Medicine, University of Colorado Denver | Anschutz Medical CampusSignature gene expression profiles in peripheral blood for distinguishing tuberculosis disease state among HIV-infected and HIV-uninfected persons in Uganda

2009 CO-Pilot Program Awards

Principal InvestigatorAffiliationProject Title
Ivor S. Douglas MD, MRCP(UK)Medical Intensive Care, Denver HealthRapid bacterial identification and antibiotic resistance testing in critically ill adults at risk for ventilator acquired pneumonia (VAP)
Robert A. Sclafani, PhDDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Denver | Anschutz Medical CampusOncology Combined Resveratrol and Radiation Therapy in Head and Neck Cancer
Kent Hansen, PhDDivision of Geriatric Medicine, Department of Medicine, School of Medicine, University of Colorado Denver | Anschutz Medical CampusEffects of Estrogen on Adipogenesis
Irene Schauer, MD, PhDDivision of Endocrine, Metabolism, and Diabetes, Department of Medicine, School of Medicine, University of Colorado Denver | Anschutz Medical CampusPostprandial lipemia and nocturnal fatty acids in type 1 diabetics compared to nondiabetic controls; a possible mechanism for increased CVD risk in type 1 diabetes
Kristen Nadeau, MDDivision of Pediatric Endocrinology, Department of Pediatrics, School of Medicine, University of Colorado Denver | Anschutz Medical CampusMuscle Metabolism in Youth with Type 1 and Type 2 Diabetes
Kerrie L. Moreau, PhDDivision of Geriatric Medicine, Department of Medicine, School of Medicine, University of Colorado Denver | Anschutz Medical CampusThe role of vascular inflammation in mediating arterial stiffening with sex hormone deficiency in healthy men
Melissa Mahoney, PhDDepartment of Chemical & Biological Engineering, University of Colorado BoulderSustained Delivery of IL10 pDNA for the Treatment of Neuropathic Pain
Leonard L. Dragone MD, PhDPediatric Rheumatology, National Jewish HealthDefining the mechanism of arthritis remission in pregnancy
Hubert Yin, PhDDepartment of Chemistry and Biochemistry, University of Colorado BoulderOptimizing the Clinical Efficacy of Opioids by TLR4 Blockade
Lucy Golden, PhDDivision of Gastroenterology & Hepatology, Department of Medicine, School of Medicine, University of Colorado Denver | Anschutz Medical CampusEngineering T Cells in Chronic HCV to Confer Novel Reactivity by Using HCV-Specific T Cell Receptor Gene Transfer
Jena French, PhDDivision of Endocrine, Metabolism, and Diabetes, Department of Medicine, School of Medicine, University of Colorado Denver | Anschutz Medical CampusImmune Suppression and Papillary Thyroid Cancer
Michelle Barron, MDDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Colorado Denver | Anschutz Medical CampusIdentifying determinants of antibiotic-associated Clostridium difficile diarrhea
Steven Moulton, MDDivision of Pediatric Surgery, Department of Pediatrics, School of Medicine, University of Colorado Denver | Anschutz Medical CampusMachine Learning Approach to the Non-Invasive Detection of Acute Blood Loss
Yiping Du, PhDDepartment of Psychiatry, School of Medicine, University of Colorado Denver | Anschutz Medical CampusDetection of Micro-hemorrhage in Traumatic Brain Injury Using Magnetic Resonance Imaging